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In pregnant rats administered semaglutide during organogenesis, embryofetal mortality, structural abnormalities and alterations to growth occurred at maternal exposures below the maximum recommended human dose (MRHD) based on AUC
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Although a BMI around 25 is generally considered desirable, in a patient who was able to reduce BMI from 40 to 32 by therapy with a GLP-1 RA, this may be sufficient to reduce secondary complications
semaglutide once-weekly as add-on therapy to metformin in people with type 2 diabetes (SURPASS-2)
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