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J Biol Chem 276 : 2099921003

How GLP-1s support weight loss When a GLP-1 binds to its receptors, it essentially mimics your bodys natural satiety signals

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GLP-1RA activate the cAMP/PKA pathway leading to phosphorylation of sodium-hydrogen exchanger 3 (NHE3) in renal proximal tubular cells, increasing natriuresis and diuresis and lowering blood pressure