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Start with the simplest effective stack and add compounds only when research goals clearly require additional mechanisms

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This study population was then divided into two cohorts: (1) Semaglutide cohort 254 patients prescribed semaglutide, and (2) non-GLP1-RA anti-diabetes medication cohort 7942 patients prescribed non-GLP-1RA anti-diabetes medications but not semaglutide

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