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Mechanistically, SM significantly enhanced -endorphin expression in the spinal dorsal horn and primary microglia [72]
In PD, the spread of the pathological alpha-synuclein from the gut to the brain is mediated along the vagus nerve
Exendin-4 has been shown to cross the blood-brain barrier (BBB) at high doses in mice [20], and exenatide demonstrates the fastest rates of brain influx compared to GLP-1 receptor agonists lixisenatide, liraglutide, and semaglutide [21]
There were significant differences between HFpEF and HFrEF for LVEDV ( p = 0.01) and LVESV ( p = 0.04)
JAMA 1999;282:21315.ArticlePubMed 4