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GLP-1, GIP & Inflammation: What These Medications Really Do and What They Dont Joshua Silva, MD Dec 5, 2025 7 min read Updated: Jan 27 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Quick Answer GLP-1 and GLP-1/GIP medications (such as semaglutide and tirzepatide ) can lower metabolic inflammation by improving insulin resistance, reducing visceral fat, and lowering inflammatory biomarkers such as C-reactive protein (CRP) ., They can also improve cardiometabolic risk markers (e.g., blood pressure) and, for tirzepatide, can improve atherogenic lipoprotein measures including apoB and triglyceride-rich lipoproteins in clinical research settings., They do not treat autoimmune diseases or fibromyalgia directly

Originally approved to help people with Type 2 diabetes, the class of medications known as GLP-1 agonists and dual GIP/GLP-1s quickly acquired a reputation for helping people shed stubborn pounds

Serious complications like pancreatitis or gallbladder issues are rare but should prompt immediate consultation with a healthcare professional

Follow aftercare advice Listening to your providers aftercare instructions is just as important as the session itself

Robert Lee and Dr