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DOI: 10.1158/0008-5472.CAN-04-2253

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Metformin appears to have a low risk of causing birth defects and is considered safer than Ozempic for use during pregnancy

The mechanisms likely involve both the hormonal disruption of rapid fat loss (fat tissue helps regulate oestrogen and testosterone) and the direct effects of GLP-1 receptor activation on dopamine-mediated sexual motivation

Patients with genetic variants associated with higher GLP-1 receptor sensitivity may experience stronger early appetite suppression, while others report a more gradual onset over 12 weeks