85,86 Conversely, hepatocyte-specific SIRT1 overexpression reduces high-fat diet-induced hepatic lipid accumulation, suggesting a protective role in hepatocytes
Furthermore, the low consumption of vegetables and fruits causes a lack of exogenous antioxidants, while an excessive intake of animal proteins (mainly red and processed meat) and fats has been associated with increased oxidants, increasing the risk of immune-mediated disorders, including autoimmune thyroid diseases [186, 187]
248,249 Obesity is another metabolic disorder associated with metabolic inflammation and has a similar phenotypic spectrum as aging, such as dysfunctional mitochondria, weakened immunity, and elevated systemic inflammation
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High-frequency data collection, such as daily diaries, offers greater insight into patient experience but also introduces additional variability
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