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Magnetic resonance spectroscopy Brain MRS PgACC/dACC/muscle data were available, respectively, for 24/23/21 ME/CFS patients, 21/17/22 long COVID patients and 24/22/23 HCs

2022;5:e221169

Some newer studies have explored spacing injections every two weeks for maintenance rather than continuing weekly doses indefinitely

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In this context, metformin emerges as the most pragmatic maintenance strategy