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Sorafenib increased macropinocytosis in human HCC specimens and xenografted HCC tissues, which prevented sorafenib-induced ferroptosis by replenishing intracellular cysteine that was depleted by sorafenib treatment
doi: 10.1016/S2213-2600(20)30161-2 219 PoeF
The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP
Susceptibility of glutatione and glutathione-related antioxidant activity to hydrogen peroxide in patients with type 2 diabetes: Effect of glycemic control
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