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The model was first generated using STEP 1 data, with internal cross-validation AUC evaluated as a metric of model precession

Several trials report meaningful fertility gains after moderate to large weight reductions, including one study that found an average 10.3% bodyweight loss associated with improved reproductive markers

Developed by Eli Lilly , it is the first treatment to combine dual agonism of GIP and GLP-1 receptors

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However, some people report other side effects, including headaches, back pain, and acid reflux