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And since the original publication offered no indication that the investigators had attempted to control for body weight changes or employed other strategies to address their potential influence on cardiovascular results, we arrived at our conclusion by applying an intuitive principle of problem-solving commonly known as Occams razor or the principle of parsimony: of two competing theories, the simpler explanation of an entity is to be preferred. 2 Yet a new analysis of SELECT trial results refutes our alternative explanationreminding us that biology is often anything but simple

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We did detect mild staining around the mouth and nose of one rat treated with 50 nmol/kg/day GEP44 and one additional rat when treated with a single 100 nmol/kg dose of GEP44