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3) Stable body weight for at least 12-months to reduce the risk of postoperative weight regain

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Activation of specific heterotrimeric G proteins involves different regions of the receptors intracellular loops, primarily the third intracellular loop (8, 50, 68)

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Extended Data Figure 4 Effects of binding pocket mutations on potency of NAMs

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The diagram in d was created using BioRender

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