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In recent years, antioxidant-based strategies have garnered considerable attention, particularly those that target endogenous antioxidant pathways, such as the GSK-3-mediated regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) axis
Its discovery by Sikiri and colleagues opened up a long line of preclinical research into cytoprotection and tissue healing
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