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A weight loss of at least 10% was achieved by 22.6% of patients in the twice-daily group, 17.4% in the once-daily group, and 9.7% in the placebo group

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More serious warnings include pancreatitis symptoms, gallbladder problems, dehydration-related kidney concerns, and hypoglycemia risk when used with insulin or sulfonylureas

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The fourth trial, EXSCEL was conducted in patients with T2DM with or without previous cardiovascular disease