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Insulin and insulin-like growth factor signalling in neoplasia
The synergistic or antagonistic effects of combined compounds must be thoroughly investigated, often requiring preliminary studies to establish safety and efficacy profiles
American Family Physician, 96(6), 384-389
Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols
This step is consistently cited as the contamination-prevention checkpoint
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