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Always consult a licensed healthcare professional before starting, stopping, or changing any treatment

Starting too aggressive can cause: Different GI effects than you're used to Unexpected energy fluctuations Appetite changes that don't match your tirzepatide experience Give yourself one week at your starting dose to see how the glucagon piece hits you specifically

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J Alzheimers Dis (2019) 70(3):793810

Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy

Its also reasonable if your Triglycerides run high and youre working on fat loss, or if you have low energy on calorie-restricted diets