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Exosomes derived from SiRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma

Serious side effects are rare but will be closely monitored

The effects, optimal dosing, safety profiles, and actual synergistic benefits of this specific combination in humans remain completely undefined without clinical trials

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Used syringes also lose their silicone coating, increasing friction and making accurate plunger control more difficult