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While early GLP1 drugs focused primarily on diabetes, newer agents, such as tirzepatidebased therapies, have gained traction in treating obesity, raising efficacy expectations and increasing competitive dynamics

The authors agree that this requires further largescale trials and cannot be claimed superior to the existing first-line conventional therapies

Some individuals may experience mild gastrointestinal discomfort or injection-site irritation depending on dosage and administration method

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Since then, my weight has been a yo-yo

However, none of the above studies investigated whether bone biomechanic and resistance to fracture were improved following administration of GLP-1Ra