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Change in other metabolic substrates and liver enzymes Serum FFA and uric acid (UA) concentrations increased significantly in both groups after fasting as shown in Table 4
Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety
Validation of obesity-related diagnosis codes in claims data