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RV-8451, differentiated oral, muscle-preserving GLP-1 candidate for obesity Recent Highlights: In February 2026, Rivus stated it was entering a pivotal year, advancing HU6 in the AMPLIFY Phase 2 MASH trial while preparing the first clinical trial for RV-8451, its muscle-preserving oral GLP-1 candidate, designed to address the muscle-loss criticism leveled at existing GLP-1 therapies

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In comparison, the unmyristoylated parent peptide 1907 displayed 0.51-fold and 0.85-fold uptake in SK-MEL-147 and WM88 cells respectively compared to TAMRA-Alkyne alone

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