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Dosage schedules of liraglutide and semaglutide In clinical practice, liraglutide and semaglutide are both self-injected GLP-1 medications, but liraglutide is administered as a once-daily injection, while semaglutide is taken once a week

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Those effects were described to be mediated via different mechanisms including downregulation of the receptor for AGE (RAGE) (112), activation of cAMP/PKA signaling and IL-6 production (113), reduction of ROS generation and ICAM-1 expression (114), and diminishing DPP-4-activated phosphatidylinositol 3-kinase signaling which favors adipocyte maturation (115)

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The triggering of these immune responses and the cellular damage in the follicles lead to an increase in oxidative stress

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