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References Li N, Yang Q, Walker RG, Thompson TB, Du M, Rodgers BD

8 Challenges in clinical application Considering the enumerated benefits of GLP-1RA compared to other glucose-lowering drugs including the reduction in HbA1c and weight reduction benefits alongside decreased risk for hypoglycaemia (122) it is not cost effective if used in combination with another incretin (107)

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That single question distinguishes a benefit exclusion, which clinical documentation cannot overcome, from a medical-necessity denial, which is appealable on clinical grounds and frequently reversible

A Novel Method for Deriving Adverse Event Prevalence in Randomized Controlled Trials: Potential for Improved Understanding of Benefit-Risk Ratio and Application to Drug Labels