Making small but meaningful changes like these can have a big impact
2020;6(16):eaba1334
Includes GHK-Cu, NAD+, MOTS-C, SS-31, and curated stacks
As a GLP-1 receptor agonist, Semaglutide GLP-1 has a variety of mechanisms of action that affect insulin secretion, glucagon production, and food intake
Particularly, the reduction of GLP-1 release over time has been an observed feature of T2DM development, as GLP-1 reduces glucagon secretion and hepatic gluconeogenesis while promoting insulin secretion, thereby effectively minimizing hyperglycemia [106]
Regarding serious renal events, although the combination showed a lower incidence (1.4 vs 2.0 events per 1000 person-years), the confidence interval was wide (HR 0.67