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A 2025 Mercer survey found that 47% of large employers covered GLP-1s for obesity, up from 34% in 2024

Semaglutide-based drugs (Ozempic, Wegovy) and tirzepatide-based drugs (Mounjaro) are generally more effective for weight loss than other GLP-1 agonists like dulaglutide or liraglutide, according to comparative trial data

But other research points in the opposite direction

Both are released in response to eating nutrientsspecifically amino acids, glucose, dietary fiber, and fatty acids in food

These trials have targeted various groups, including individuals with diabetes, focusing on cognitive effects, and those with or at risk of AD or PD (summarized in Table 2 for AD and Table 3 for PD)