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What does clinical evidence say about GLP-1 dosing flexibility

Sleep quality is closely linked to body weight, and excess weight can contribute to poor sleep patterns, frequent waking, and reduced sleep depth

Heart (2022) 108:91722

PLoS ONE 6:e16957 Ramsay RR, Gandour RD, van der Leij FR (2001) Molecular enzymology of carnitine transfer and transport

Whilst achieving a healthy weight before conception is associated with better fertility outcomes and reduced pregnancy complications, weight loss medications (including GLP-1 receptor agonists, tirzepatide, naltrexone/bupropion, and orlistat) are not recommended when actively trying to get pregnant

In addition, there is a U-shaped association between selenium exposure and some diseases, such as type 2 diabetes and fractures [117]