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Case presentation SL was a 44 year old Caucasian male with a past medical history of severe morbid obesity (BMI 99), heart failure with preserved ejection fraction, oxygen-dependent obesity hypoventilation syndrome (OHS), chronic non-healing leg wounds, anemia, uncontrolled hypertension on 2 anti-hypertensive agents, limited mobility, and major depressive disorder who presented to an academic medical center for treatment of acute on chronic diastolic heart failure due to progressive dyspnea

Sex, age, and comorbidity should not be treated as nuisance variables

The drug label advises against using tirzepatide with other weight loss treatments, including GLP-1 agonists

Both medications may cause serious side effects, including chest pain, swelling of the legs or ankles, irregular heartbeat, and mental or mood changes

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