doi: 10.1093/brain/awv222 132 CohenTJGuoJLHurtadoDEKwongLKMillsIPTrojanowskiJQet al
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Under basal homeostatic conditions, Nrf2 is sequestered in the cytoplasm through its interaction with the adaptor protein KEAP1 (Kelch-like ECH-associated protein 1), which targets Nrf2 for ubiquitination and subsequent proteasomal degradation
Intravenous glutathione is not approved by the TGA for skin whitening or lightening, and high-dose intravenous glutathione has been associated with reports of serious side effects overseas, including effects on the liver, kidneys and thyroid and, rarely, severe skin reactions
Their prolonged persistence in the environment, coupled with bio-enrichment of food chains, is resulting in a risk to human health
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