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Interestingly, clinical studies in patients with neurodegenerative diseases (NDD) who do not suffer from diabetes mellitus have shown the neuroprotective effect of GLP-1RAs, independent of blood glucose levels [31]

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GLP-1 activates the GLP-1 receptor (GLP-1R) in a glucose-dependent manner to potentiate insulin release and suppress glucagon secretion, and thereby lead to blood sugar lowering and weight loss [3][4]

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