You should specifically discuss Wegovy with your GP if you: Are currently taking any thyroid medication , including levothyroxine, liothyronine, or antithyroid drugs Have a history of thyroid disease or thyroid nodules Have experienced thyroid function changes in the past with weight fluctuations Are planning pregnancy (semaglutide should be discontinued at least 2 months before planned conception, and effective contraception should be used while on treatment) During Wegovy treatment , contact your GP promptly if you experience: Symptoms suggesting thyroid dysfunction : unexplained fatigue, cold intolerance, hair loss, palpitations, anxiety, or tremor Neck symptoms : swelling, lumps, difficulty swallowing, or persistent hoarseness Significant changes in how you feel on your thyroid medication, suggesting your dose may need adjustment Difficulty tolerating Wegovy side effects, particularly if they interfere with taking your thyroid medication properly Seek urgent medical attention if you develop: Severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis Jaundice (yellowing of skin/eyes) or severe right upper abdominal pain, which might suggest gallbladder problems Your GP may arrange thyroid function blood tests if you develop symptoms or as part of routine monitoring
Two participants experienced more significant adverse events possibly related to semaglutide but were able to continue in the study
Because of these limitations, there was a desire for a GLP-1 agonist that could be taken orally at any time of the day without any food or water restrictions
Br J Pharmacol 160:20692084 Pu S, Pan Y, Zhang Q, You T, Yue T, Zhang Y et al (2023) Endoplasmic reticulum stress and mitochondrial stress in drug-induced liver injury
Found is among the largest medically-supported telehealth weight care platforms in the country, having served more than 250,000 members to date
In particular, tirzepatide 15 mg was associated with at least twofold higher odds of study drug discontinuation regardless of comparator
