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L-carnitine is available both as food supplements and as levocarnitine, an MHRA-licensed medicine used to treat primary and secondary carnitine deficiency
Up-regulated GCL expression to ensure GSH elevation under conditions of inflammatory and oxidative stimulation seems reasonable, as GCL activity is considered especially important for maintaining GSH levels to provide relevant antioxidant defense
However, excessive autophagy may induce ferroptosis
Glutathione, a tri-peptide molecule consisting of the amino acids L-glycine, L-csyteine, and L-glutamic acid (also known as L-glutamate), is the major intracellular antioxidant in humans
Therefore, in the process of developing ferroptosis-related drugs with the potential to target endometriosis, a series of downstream reactions caused by ferroptosis in ectopic endometrial tissue should be considered, and these issues need to be further resolved in the future
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