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Based on the present steady-state data, we compared the developed population PK model to a one-compartment PK model similar to the one estimated in the phase 3 analysis [6] with almost identical results

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From a physiologic point of view, you're in positive energy balance

Maintenance of high GSH levels seems to be of high priority to the antioxidant defense system under UA treatment

They did not keep losing at the initial rate, but they did not regain weight either

We performed separate analyses based on type of comparator (placebo, GLP-1 RA or basal insulin) and subgroup analyses based on tirzepatide maintenance dose (5, 10 or 15 mg once-weekly)