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The extensive list of Hashimotos symptoms includes: Fatigue Increased sleepiness Unexplained weight gain Constipation Increased sensitivity to cold Difficulty getting warm Joint pain or stiffness Muscle pain or weakness Puffy eyes and face Dry skin Brittle hair and nails Hair loss Slow heart rate Irregular menstruation, including heavy flow Difficulty getting pregnant Difficulty concentrating Memory problems Enlargement of your tongue Enlarged thyroid (goiter) Depression Sexual dysfunction in both men and women Untreated Hashimotos disease can result in these severe complications: Myxedema coma , which, in rare cases, diminishes your mental state, dangerously lowers your body temperature, and requires immediate emergency care Heart problems , such as enlarged heart, high cholesterol, heart failure, or other heart diseases Mental health issues , including worsening depression Goiter , where your thyroid swells and appears as a large visible bump on your neck Sexual dysfunction , including reduced libido, irregular and excessive menstrual bleeding (in women), and erectile dysfunction (in men) Reproductive dysfunction , including inability to ovulate and increased risk of miscarriage or premature birth Birth abnormalities , meaning that babies born to women with untreated hypothyroidism have a higher risk of autism and other developmental disorders Root Causes of Hashimotos Disease & Hypothyroidism There is not one single culprit which causes the immune system to attack thyroid cells

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What Can In Vitro Models Clarify

AMPK activation influences glucose uptake, fatty acid oxidation, autophagy, and inflammatory gene expression [2]

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