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Two discoveries emerged: Combined treatment (GLP-1 drug + anti-CRH) produced greater weight loss and importantly, better weight loss quality, meaning more fat loss and less muscle loss
Its mechanism simultaneously targets: GLP-1 receptors: improving insulin secretion, lowering blood glucose, and suppressing appetite GCG receptors: increasing energy expenditure, promoting fat oxidation, and improving hepatic lipid metabolism Approved indications in China include: Long-term weight management in overweight or obese adults Blood glucose control in type 2 diabetes Clinical trial findings related to Mazdutide have been published in leading journals including Nature, The New England Journal of Medicine, and JAMA
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