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Endocrine-disrupting chemicals and thyroid function According to the Endocrine Society, Endocrine-disrupting chemicals (EDCs) are defined as a mixture of chemicals or an exogenous chemical that can interfere with any aspect of hormone action (88)

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Within the liver, as well as other tissues such as the kidneys, adipose tissue, and the vasculature, high levels of uric acid are associated with increased mitochondrial stress resulting in elevation in reactive oxygen species (ROS) production