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Roche is advancing an oral GLP-1 receptor agonist, CT-996, which it gained through its 2024 acquisition of Carmot Therapeutics, a Berkeley, California-based bio/pharmaceutical company, in a deal worth up to $3.1 billion ($2.7 billion at closing plus $400 million in potential milestone payments)

The specialized nature of producing these peptides has led to some quality control issues with compounders

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The most significant ongoing concern is muscle loss during rapid weight reduction, which is why nutritional support and physician monitoring throughout treatment remain essential regardless of how long treatment lasts

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