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In a landmark study called the STEP program, which included over 4500 adults with overweight or obesity, glp-1 was found to lead to significant weight loss compared to a placebo

In the SURMOUNT-1 clinical trial, participants using tirzepatide lost an average of up to 24.3% of their body weight over 72 weeks

In clinical practice, tirzepatide is often chosen over semaglutide when maximum efficacy for weight loss is the primary goal

Tailored resistance exercise training can optimize changes in body composition by preserving lean mass while achieving fat loss when associated to hypocaloric diet or incretin therapy [38, 39]

The calculations use published half-life data and standard PK models, but individual responses vary