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The following decades of research shifted the interest from isolated observations to a broad profile: stimulation of the synthesis of extracellular matrix proteins, modulation of the expression of genes related to tissue repair and the function of a carrier of copper ions into cells
Glutathione also helps maintain and regenerate other important antioxidants, including vitamins C and E the three nutrients even have a sparing effect on one another, filling in to keep levels of each close to optimal
Brain Res (2016) 1634:15870
On the other hand, direct delivery of low concentrations of drugs to the target site produces the greatest accumulation of therapeutic effects through minimum doses and reduces the risk of toxicity and systemic exposure (Cipolla et al., 2013)
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