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For decades, spironolactone has been one of the main drugs targeting this pathway

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Two randomized controlled trials demonstrated reduced bone loss during weight loss with GLP-1 RA compared to placebo (51, 52)

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While this hasnt been confirmed in humans, these medications are not recommended for those with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

Shibbani K, Fahed AC, Al-Shaar L et al : Primary carnitine deficiency: novel mutations and insights into the cardiac phenotype