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We will examine the results from major clinical trials involving thousands of patients

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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

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4 Mitochondrial dysfunction Mitochondrial dysfunction is a prominent event of TBI, resulting in disruptions to physiological and metabolic processes and ultimately culminating in cell death