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13 Another study found that patients with MDD had significantly lower plasma levels of ALC compared to healthy controls, and these levels were inversely correlated with depression severity and duration

Most of the acetyl-CoA produced by ACL originally derives from glucose or glutamine carbon

(2010) Nutrition and Hair

These metabolic alterations may be closely linked to the pathophysiological mechanisms underlying depression [393, 394]

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This means that if we try to optimize a non-convex function, we may get stuck in a local minimum and miss the global minimum, which is the optimal solution we are looking for