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However, oral bioavailability is only about 1%, meaning you need a much higher absolute dose to achieve comparable blood levels to the injectable form
Its value is in identifying functional pathway abnormalities that may deserve further investigation or nutritional support
The result isn't simply a lower body weightit can be a healthier body composition with less fat and more lean tissue
The result: you're eating fewer total calories (sometimes), but the ratio is wrong
If you've been following the diabetes and weight loss medication space, you've seen the evolution
An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]
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