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In primary care, orlistat is commonly prescribed, working by inhibiting pancreatic lipase to reduce dietary fat absorption
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This phenomenon, sometimes called tolerance or tachyphylaxis, is not well-studied specifically for semaglutide, but it is reported frequently in practice
GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)are temperature-sensitive biologic medications used for type 2 diabetes and weight management
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