These changes result from improved skin function, not from altering melanin activity
In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
Individual outcomes vary depending on metabolism, skin condition, and lifestyle factors
We are including protein anyway because leaving it out would make this guide dishonest
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