Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45
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Priscilla DH, Prince PSM
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A deficiency can have serious consequences for health, it is essential to quickly restore the balance
This difference in subcellular localization, combined with its distinct expression patterns, suggests that the two proteins play different roles in regulating cellular GSH levels (Ward et al., 2024)