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In the brain, melatonin is an important physiological antioxidant due to its lipid and water-soluble properties ability to freely cross the blood-brain barrier
When applied as a cream, glutathione acts only superficially, as the glutathione molecule is too large to penetrate the skin barrier in significant amounts
BMC Microbiol 23 , 187 (2023)
Rather than declaring an overall winner, the evidence points toward each antioxidant excelling in different areas
There are similar studies showing that arhalofenate acid activates AMPK in macrophages in vitro , inhibits the activation of NLRP3 inflammasomes, and reduces MSU-induced IL-1 production ( Colchicine can inhibit the release of IL-1-induced MSU crystal deposition joints
Quick and Convenient : Each session is quick, and because the downtime is minimal, patients can typically return to their normal activities immediately after the procedure
