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Furthermore, in the same study, expression of poly (GR) 80 in neurons increased ROS levels, inducing oxidative stress and dysregulating redox conditions in C9orf72 iPSCs (Lopez-Gonzalez et al., 2016)
The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
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