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Greenberg NR et al
The most common GLP-1 side effects include: Nausea Diarrhea Vomiting Constipation Stomach pain A study from researchers at Mayo Clinic, presented in 2023, found that half of adults taking semaglutide, the active ingredient in Ozempic and Wegovy, experienced side effects, the most reported ones being nausea (38 percent) and diarrhea (9 percent)
While natriuresis is a normal biological function of healthy kidneys, GLP-1 drugs appear to modestly enhance this process
25,26 Furthermore, a polymorphism of the DHFR enzyme resulting in a 19bp deletion within the site of a key regulatory sequence has been theorized to exhibit negative effects on the expression and activity of this enzyme
Pankiv, S
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