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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
Ditzenberger GL, Lake JE, Kitch DW, Kantor A, Muthupillai R, Moser C, et al
A metastasis-prone signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics
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