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C12 stimulate GLP-1 secretion, whereas C10 do not.56 Regarding the relationship between GLP-1 and macronutrients in controlling food intake, a study showed that maintenance on high-fat diet in rats impairs GLP-1s ability to reduce food intake, contributing to overconsumption of high-fat foods.80 Gut hormones and obesity The epidemic obesity is fastly becoming one of the leading causes of mortality and morbidity worldwide