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The C-terminal amidation is critical for full biological activity, as the free-acid form shows significantly reduced receptor binding
Vitamin B12 deficiency results in megaloblastic anemia, GI lesions, and neurologic damage (which begins with an inability to produce myelin and is followed by gradual degeneration of the axon and nerve head)
It cannot legally be marketed as a drug or medicine
A., Melville, A
They describe laboratory findings related to peptide signaling, cellular behavior, and structural pathway studies
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